Design, synthesis and evaluation of 9-hydroxy-7H-furo[3,2-g]chromen-7-one derivatives as new potential vasodilatory agents

作者：Wang Cheng; Wang Tao; Zhou Nan; Pan Xiao Yan; He Huai Zhen^*

来源：Journal of Asian Natural Products Research, 2014, 16(3): 304-311.

DOI：10.1080/10286020.2013.874345

• 9-hydroxy-7H-furo[3
• 2-g]chromen-7-one
• vasodilatory activity
• synthesis
• molecule docking

Two new 9-hydroxy-7H-furo[3,2-g]chromen-7-one derivatives were designed, synthesized and evaluated for their in vitro vasodilatory activity. The structures of two compounds were elucidated by infrared, H-1 NMR, and mass spectral data. The invitro pharmacological evaluation indicated that both of them possessed well vasodilatory activity compared with imperatorin. The molecule docking also showed two target compounds docked well with L-calcium channel (PDB code: 3G43). The result suggested that they would be potential vasodilatory agents for hypertension.

• 出版日期2014-3-4
• 单位西安交通大学