Alzheimer disease prevention: Focus on cardiovascular risk, not amyloid?

作者:Geldmacher David S*
来源:Cleveland Clinic Journal of Medicine, 2010, 77(10): 689-+.
DOI:10.3949/ccjm.77gr.2010

摘要

Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.

  • 出版日期2010-10