Hydroa Vacciniforme Is Associated with Increased Numbers of Epstein-Barr Virus-Infected gamma delta T Cells

作者：Hirai Yoji; Yamamoto Takenobu; Kimura Hiroshi; Ito Yoshinori; Tsuji Kazuhide; Miyake Tomoko; Morizane Shin; Suzuki Daisuke; Fujii Kazuyasu; Iwatsuki Keiji^*

来源：Journal of Investigative Dermatology, 2012, 132(5): 1401-1408.

DOI：10.1038/jid.2011.461

Hydroa vacciniforme (HV) is a rare photosensitivity disorder of childhood associated with Epstein-Barr virus (EBV)(+) T-cell infiltration. We have summarized clinical manifestations of HV, and analyzed EBV+ T-cell subsets as well as EBV DNA load in lymphocyte fractions, in comparison with hypersensitivity to mosquito bites (HMB), an EBV-associated T/natural killer (NK) lymphoproliferative disorder. We found that 31 of 33 (93.9%) HV lesions were composed of EBV+ T cells and reactive EBV- cytotoxic T cells, without significant CD56(+) cell infiltration, whereas many CD56(+) cells were present in 8 of 9 (88.9%) HMB lesions. Of 13 (20.6%) HMB patients with or without HV, 12 (92.3%) showed increased percentages (%26gt;32%) of NK cells in the peripheral blood, whereas in the 16 patients with HV alone, 14 (87.5%) showed no increase. Of the 11 HV patients, 10 (90.9%) had increased percentages (%26gt;5%) of circulating gamma delta T cells, with a mean value of 15.7 +/- 2.9%, and the gamma delta T-cell fractions contained larger amounts of EBV DNA than non-gamma delta T-cell fractions. A triple-labeling method revealed that all three HV patients examined had increased percentages of EBER+, T-cell receptor (TCR) gamma delta(+), and TCR alpha beta(-) cells. Our observations indicate that HV is associated with increased numbers of EBV+ gamma delta T cells, whereas HMB is associated with EBV+ NK cells.

• 出版日期2012-5