ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A

作者：Merle Nicolas; Feraud Olivier; Gilquin Benoit; Hubstenberger Arnaud; Kieffer Jacquinot Sylvie; Assard Nicole; Bennaceur Griscelli Annelise; Honnorat Jerome; Baudier Jacques^*

来源：Mitochondrion, 2012, 12(4): 441-448.

DOI：10.1016/j.mito.2012.05.005

• ATAD3A
• ATAD3
• HSP60
• Stem cells
• Mitochondria
• Glioma

Here we report on the identification of a human pluripotent embryonic stem cell (hESC) specific mitochondrial protein that is re-expressed in cancer cells, ATAD3B. ATAD3B belongs to the AAA+ATPase ATAD3 protein family of mitochondrial proteins specific to multicellular eukaryotes. Using loss- and gain-of-function approaches, we show that ATAD3B associates with the ubiquitous ATAD3A species, negatively regulates the interaction of ATAD3A with matrix nucleoid complexes and contributes to a mitochondria fragmentation phenotype. We conclude that ATAD3B is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in hESCs and cancer cells.

• 出版日期2012-7
• 单位中国地震局