Association Between Perinatal Hypoxic-Ischemic Conditions and Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis

作者：Zhu, Tingting; Gan, Jing; Huang, Jichong; Li, Yafei; Qu, Yi; Mu, Dezhi^*

来源：Journal of Child Neurology, 2016, 31(10): 1235-1244.

DOI：10.1177/0883073816650039

• hypoxia
• ischemia
• risk factor
• ADHD
• meta-analysis

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder worldwide, but its etiology is still not fully understood. Previous studies have reported that perinatal hypoxic-ischemic conditions may be a potential cause of ADHD. @@@ Methods: An online search of potential English studies published before September 2015 was conducted using the PsycINFO, EMBASE, Web of Science, and PubMed databases. The combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models. @@@ Results: Ten studies were included, with 45 821 cases and 9 207 363 controls. The metaresults found that the following were associated with ADHD: preeclampsia (OR 1.31; 95% CI 1.26-1.37), an Apgar score <7 at 5 minutes (OR 1.31; 95% CI 1.12-1.54), breech/transverse presentations (OR 1.14; 95% CI 1.06-1.23), and a prolapsed/nuchal cord (OR 1.10; 95% CI 1.06-1.15). @@@ Conclusion: Our results support that perinatal hypoxia-ischemia may contribute to ADHD. However, more clinical studies are warranted.

• 出版日期2016-9
• 单位四川大学