Adjuvant Endocrine Therapy for Breast Cancer During Perimenopause

作者：Noss D; Buchholz S; Ortmann O^*

来源：Geburtshilfe und Frauenheilkunde, 2010, 70(2): 112-116.

DOI：10.1055/s-0029-1240825

• perimenopause
• breast cancer
• endocrine therapy
• menopausal status

Adjuvant endocrine treatment plays an important role in the treatment of estrogen responsive breast cancer. The treatment options for premenopausal women differ from those for postmenopausal women. Aromatase inhibitors (AI) improve the outcomes in postmenopausal women, while AI can induce an increase in estrogen secretion and tumor growth in premenopausal women. The standard therapy during premenopause remains tamoxifen with or without ovarian suppression by GnRH analogues. Treatment of perimenopausal breast cancer patients can be more complicated, because it is often difficult to determine menopausal status.

• 出版日期2010-2