Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients

作者：Hemminki Kari^*; Sundquist Jan; Bermejo Justo L

来源：British Journal of Haematology, 2009, 147(4): 526-530.

DOI：10.1111/j.1365-2141.2009.07874.x

• polycythaemia vera
• myelofibrosis
• leukaemia
• family history
• discordant cancers

Polycythaemia vera (PV) and primary myelofibrosis (MF) show concordant familial clustering but limited population level data are available on the aggregation of other discordant neoplasms in these families. We used the Swedish Family-Cancer Database to assess risks for VP and MF in families of cancer patients. A total of 3530 first PV and 1606 MF patients were identified, with high concordant familial risks. Several discordant familial associations were found for PV (acute myeloid leukaemia, Hodgkin disease, prostate and bladder cancers) or for MF (chronic lymphatic leukaemia, colorectal, kidney and cervical cancers) or for both (nervous system, eye and endocrine tumours).

• 出版日期2009-11
• 单位河北医科大学