An efficient synthesis of pyrazolo[3,4-b]pyridine-4-spiroindolinones by a three-component reaction of 5-aminopyrazoles, isatin, and cyclic beta-diketones

作者：Quiroga Jairo^*; Portillo Sandra; Perez Alfredo; Galvez Jaime; Abonia Rodrigo; Insuasty Braulio

来源：Tetrahedron Letters, 2011, 52(21): 2664-2666.

DOI：10.1016/j.tetlet.2011.03.067

• Pyrazolopyridine-spiroindolinone
• Isatin
• 5-Aminopyrazoles
• Cyclic beta-diketones

Novel pyrazolopyridine-spiroindolinones were prepared by the three-component reaction of 5-aminopyrazoles, isatin, and cyclic beta-diketones in aqueous media and catalyzed by p-TSA. This protocol provides a simple one-step procedure with the advantages of easy work-up, mild reaction conditions and environmentally benign.

• 出版日期2011-5-25