A novel method for the synthesis of 3-fluoro-4-aryl-2-pyridone via unprecedented denitration

作者：Wang Xiao Wei; Cui Hai Feng; Wang Hai Feng; Yang Ying Quan; Zhao Gang; Zhu Shi Zheng^*

来源：Tetrahedron, 2011, 67(13): 2468-2473.

DOI：10.1016/j.tet.2011.01.047

• Cyclization
• Denitration
• Fluorine-containing 2-pyridone
• alpha,beta-Unsaturated ketone

A simple and novel method to the synthesis of 3-fluoro-4-aryl-2-pyridone from a Michael-adduct of fluoronitroacetate and alpha,beta-unsaturated ketone is reported. With (NH(4))(2)CO(3) as the N-source and TsOH as the promoted acid, a series of fluorinated-pyridones was obtained with moderate to good yields.

• 出版日期2011-4-1
• 单位中国科学院