Association between the serotonin 1A receptor (C-1019)G polymorphism and major depressive disorder in the northern Han ethnic group in China

作者：Wu Ying; Xu Yong; Sun Yan; Wang Yan-fang; Li Xia; Lang Xiao-e; Wang Wei-ping; Zhang Ke-rang^*

来源：Chinese Medical Journal, 2008, 121(10): 874-876.

DOI：10.1097/00029330-200805020-00002

• major depressive disorder
• serotonin receptor
• gene polymorphism

Background Recent studies have suggested that susceptibility to major depressive disorder (MDD) might be related to the serotonin 1A receptor (5-HTR1A) C(-1019)G polymorphism. In this study, we aimed to assess the association between 5-HTR1A C(-1019)G polymorphism and MDD in the Northern Han ethnic group of China. @@@ Methods The C(-1019)G of 5-HTR1A was detected with polymerase chain reaction (PCR) in 400 patients with MDD and 400 unrelated age- and sex-matched healthy control subjects. Association between the C(-1019)G and MDD was statistically analyzed. @@@ Results There was a statistically significant difference between MDD patients and controls in both the genotype distribution (X-2=10.913, df=2, P=0.004) and the allele frequency (X-2=10.379, df=1, P=0.001), and a significant difference in the genotype distribution and the allele frequency was found both in the female subjects (Genotype distribution: X-2=15.406, df=2, P=0.000; allele frequency: X-2=15.552, df=1, P=0.000) and the late-onset subjects (Genotype distribution: X-2=7.771, df=2, P=0.021; allele frequency: X-2=8.007, df=1, P=0.005) in the two groups. @@@ Conclusion These results suggest that 5-HTR1AC(-1019)G polymorphism is probably associated with MDD and it is likely to be the susceptible gene locus for the female and late-onset MDD.

• 出版日期2008-5-20
• 单位山西医科大学