A new oleanolic-type triterpene glycoside from Anchusa italica

作者:Chen, Kui-Kui; Xie, Zhou-Jian; Dai, Wei; Wang, Qi*
来源:Natural Product Research, 2017, 31(8): 959-965.
DOI:10.1080/14786419.2016.1258557

摘要

A new oleanolic-type triterpene glycoside, (3,21)-21-[(-d-glucopyranosyl-(12)--d-glucopyranosyl)oxy]-3-hydroxyolean-12-en-28-oic acid (1), together with five analogues, oleanazuroside 1 (2), oleanazuroside 2 (3), 24-hydroxytormentic acid ester glucoside (4), 24-epi-pinfaensin (5), and oleanolic acid 3-O--l-arabinoside (6) were isolated from the n-butyl alcohol extract of Anchusa italica. Their structures were determined spectroscopically and compared with previously reported spectral data. Compounds 3-4 and 6 were evaluated for their cytotoxic activities against five human cancer cell lines, but only compound 6 showed moderate cytotoxicity.