Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner

作者：Xu, Zhiping; Shi, Lina; Jiang, Danping; Cheng, Jiagao; Shao, Xusheng^*; Li, Zhong

来源：Scientific Reports, 2015, 5(1): 13962.

DOI：10.1038/srep13962

• OPTICAL CONTROL
• ION CHANNELS
• PHOTOCHEMICAL CONTROL
• PEPTIDE CONFORMATION
• BIOLOGICAL-ACTIVITY
• REMOTE-CONTROL
• LIGHT
• PHOTOCONTROL

Incorporating the photoisomerizable azobenzene into imidacloprid produced a photoswitchable insecticidal molecule as the first neonicotinoid example of remote control insecticide performance with spatiotemporal resolution. The designed photoswitchable insecticides showed distinguishable activity against Musca both in vivo and in vitro upon irradiation. Molecular docking study further suggested the binding difference of the two photoisomers. The generation of these photomediated insecticides provides novel insight into the insecticidal activity facilitating further investigation on the functions of insect nicotinic acetylcholine receptors and opens a novel way to control and study insect behavior on insecticide poisoning using light.

• 出版日期2015-10-5
• 单位华东理工大学