科研之友
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摘要
The proper localization of RNA transcripts is a highly controlled and fine-tuned process. Indeed, regulation of RNA trafficking is mediated by both cis-acting elements and trans-acting factors, and defects in either mechanism have been associated with disease. Identifying the RNA sequence motifs that determine cellular localization for a given transcript therefore represents an important and challenging task. A new study from Shukla etal in The EMBO Journal-along with related work from Lubelsky and Ulitsky published elsewhere-describes a new screen that uses hybrid RNAs with barcoded oligonucleotides to identify cis-acting elements that increase the propensity of RNAs to be retained in the nuclear compartment.
- 出版日期2018-3-15
