Adenosinergic regulation of the cardiovascular system in the red-eared slider Trachemys scripta

作者：Joyce William^*; Wang Tobias

来源：Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 2014, 174: 18-22.

DOI：10.1016/j.cbpa.2014.04.002

• Turtle
• Reptile
• Adenosine
• Cardiovascular

Few studies have investigated adenosinergic regulation of the cardiovascular system in reptiles. The haemodynamic effect of a bolus intra-arterial adenosine injection (2.5 mu M kg(-1)) was investigated in nine anaesthetised red-eared sliders (Trachemys scripta). Adenosine caused a transient bradycardia, which was accompanied by systemic vasodilatation as evidenced by an increase in systemic flow and a decrease in systemic pressure. Meanwhile, pulmonary flow fell significantly. Both the bradycardia and increase in systemic conductance were significantly attenuated by theophylline (4 mg kg(-1)), demonstrating an involvement of P-1 receptors. These results suggest that adenosine is likely to play a significant role in reptile cardiovascular physiology. In turtles specifically, adenosinergic regulation may be particularly relevant during periods of apnoea.

• 出版日期2014-8