Hepatocellular carcinoma surveillance rates in commercially insured patients with noncirrhotic chronic hepatitis B

作者：Goldberg D S^*; Valderrama A; Kamalakar R; Sansgiry S S; Babajanyan S; Lewis J D

来源：Journal of Viral Hepatitis, 2015, 22(9): 727-736.

DOI：10.1111/jvh.12381

• chronic hepatitis B
• hepatocellular carcinoma
• surveillance
• Ultrasound

American association for the study of liver diseases (AASLD) and European Association for the Study of the Liver (EASL) guidelines recommend biannual hepatocellular carcinoma (HCC) screening for noncirrhotic patients with chronic hepatitis B infection (HBV), yet there are no data estimating surveillance rates or factors associated with surveillance. We performed a retrospective cohort study of US patients using the Truven Health Analytics databases from 2006 to 2010 and identified patients with noncirrhotic chronic HBV. Surveillance patterns were characterized using categorical and continuous outcomes, with the continuous measure of the proportion of time up to date' with surveillance (PUTDS), with the 6-month interval following each ultrasound categorized as up to date'. During a median follow-up of 26.0 (IQR: 16.2-40.0) months among 4576 noncirrhotic patients with chronic HBV (median age: 44years, IQR: 36-52), only 306 (6.7%) had complete surveillance (one ultrasound every 6-month interval), 2727 (59.6%) incomplete (1 ultrasound) and 1543 (33.7%) none. The mean PUTDS was 0.34 +/- 0.29, and the median was 0.32 (IQR: 0.03-0.52). In multinomial logistic regression models, patients diagnosed by a nongastroenterologist were significantly less likely to have complete surveillance (P<0.001), as were those coinfected with HBV/HIV (P<0.001). In linear regression models, nongastroenterologist provider, health insurance subtype, HBV/HIV coinfection, rural status and metabolic syndrome were independently associated with decreased surveillance. Patients with HIV had an absolute decrease in the PUTDS of 0.24, while patients in less populated rural areas had an absolute decrease of 0.10. HCC surveillance rates in noncirrhotic patients with chronic HBV in the United States are poor and lower than reported rates of HCC surveillance in cirrhotic patients.

• 出版日期2015-9