Association of intralipid intake in extremely low birthweight infants withneurodevelopmental outcomes

作者：Oh William^*; Przystac Lynn; McKinley Leslie; Tucker Richard; McGowan Elisabeth C; Vohr Betty R

来源：Acta Paediatrica, 2018, 107(4): 600-604.

DOI：10.1111/apa.14201

• Cognitive score
• Extremely low birthweight
• Language score
• Lipid infusion

Aim: To determine whether high intake of intralipid (IL) in extremely low birthweight (ELBW) neonates is associated with higher rates of neuroimpairment and Bayley III scores at two years of corrected age.
Methods: Quartiles of IL received by 389 ELBW infants were linked to neurodevelopmental outcomes. Logistic regression analyses, adjusted for confounders, were performed to determine the association between IL dose and neuroimpairment. Linear regression analyses were performed to predict Bayley III scores.
Results: No association was found between IL dose and neuroimpairment A significant association was found between higher IL intake and lower Bayley Cognitive, motor and language scores. Adding breast milk intake to the linear regression eliminated the associations.
Conclusion: Higher IL intake was associated with lower cognitive, motor and language scores. Breast milk intake eliminated the latter associations, which underscores the important role of breast milk in developmental outcome.

• 出版日期2018-4