Molecular characterization of a new D- - haplotype in a Comorian man

作者：Silvy M; Chapel Fernandes S; Beley S; Durousseau C; Granier T; Zappitelli J P; Bailly P; Chiaroni J^*

来源：Vox Sanguinis, 2012, 103(4): 352-355.

DOI：10.1111/j.1423-0410.2012.01620.x

• RHD - - haplotype
• RhD epitope density
• RhD overexpression
• zygosity

The D- - phenotype is a genetic variant of the Rh blood group system. It expresses D antigen but lacks C, c, E and e antigens. In D- - phenotype, the RHCE coding region is extensively modified by RHD sequence replacement, nucleotide deletion or splice-site changes. This article reports the identification of a new D- - haplotype in a Comorian man. It exhibits a hybrid gene in which RHCE gene exons 38 have been replaced by RHD sequences on the RHCE * C allele background. This allele is associated with no expression of c/C and e/E antigens and overexpression of RhD antigen.

• 出版日期2012-11