Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

作者：Dixon Suen Suzanne C; Nagle Christina M; Thrift Aaron P; Pharoah Paul D P; Ewing Ailith; Pearce Celeste Leigh; Zheng Wei; Chenevix Trench Georgia; Fasching Peter A; Beckmann Matthias W; Lambrechts Diether; Vergote Ignace; Lambrechts Sandrina; Van Nieuwenhuysen Els; Rossing Mary Anne; Doherty Jennifer A; Wicklund Kristine G; Chang Claude Jenny; Jung Audrey Y; Moysich Kirsten B; Odunsi Kunle; Goodman Marc T; Wilkens Lynne R; Thompson Pamela J

来源：British Journal of Cancer, 2018, 118(8): 1123-1129.

DOI：10.1038/s41416-018-0011-3

BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.
METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.
RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.
CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

• 出版日期2018-4