AlncRNA HULC as an effective biomarker for surveillance of the outcome of cancer: A meta-analysis

作者：Chen, Xiaoliang; Lin, Jinbo; Liu, Yi; Peng, Ji; Cao, Yong; Su, Zhan; Wang, Tieqiang; Cheng, Jinquan^*; Hu, Dongsheng^*

来源：PLos One, 2017, 12(2): e0171210.

DOI：10.1371/journal.pone.0171210

• LONG NONCODING RNA
• LYMPH-NODE METASTASIS
• POOR-PROGNOSIS
• PREDICT
• PROGRESSION
• CARCINOMA
• H19

Purpose High expression of highly upregulated in iver cancer (HULC) has been found associated with increased metastasis and poor prognosis with cancer. This meta-analysis aimed to determine the pooled effect of HULC on metastasis and prognosis of cancers. @@@ Method The studies were accessed using multiple databases. RevMan5.3 and STATA14.0 were used to estimate pooled effects, the heterogeneity among studies, and publication bias for the association of HULC and overall survival (OS). @@@ Results A total of 9 studies of 966 cancer patients were included. Risk of lymph node metastasis was increased with high versus low HULC expression (pooled odds ratio [OR] = 4.83, 95% confidence interval [CI] 1.59-14.63) as was distant metastasis (pooled OR = 5.44, 95% CI 2.33-12.74). Furthermore, OS time was shortened with high HULC expression (pooled hazard ratio [HR] = 1.48, 95% CI 1.03-2.12), especially in Chinese patients (pooled HR = 2.04, 95% CI 1.55-2.68), and risk of recurrence was increased (pooled OR = 6.68, 95% CI 2.77-16.13). @@@ Conclusion HULC might be a potential biomarker for therapy and prognosis surveillance in cancers.

• 出版日期2017-2-1
• 单位深圳大学; 深圳市疾病预防控制中心