A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

作者:Friscic Tomislav*; Halasz Ivan; Strobridge Fiona C; Dinnebier Robert E; Stein Robin S; Fabian Laszlo; Curfs Caroline
来源:CrystEngComm, 2011, 13(9): 3125-3129.
DOI:10.1039/c0ce00894j

摘要

Variation of water content in liquid-assisted grinding was utilised to mechanochemically screen for different hydrated forms of magnesium naproxen directly from a mixture of magnesium oxide and naproxen. Structure determination from powder and single crystal X-ray diffraction data, supported by solid-state NMR and synchrotron radiation diffraction experiments, revealed a monohydrate coordination polymer, a discrete tetrahydrate complex, and provided a preliminary structural model for a highly hydrated salt.

  • 出版日期2011-5