A trans-chelating bisphosphine possessing only planar chirality and its application to catalytic asymmetric reactions

作者：Kuwano R; Uemura T; Saitoh M; Ito Y^*

来源：Tetrahedron: Asymmetry , 2004, 15(14): 2263-2271.

DOI：10.1016/j.tetasy.2004.04.033

A new chiral bisphosphine, (S,S)-2,2"-bis[(diethylphosphino)methyl]-1,1"-biferrocene [(S,S)-EtTRAP-H], was synthesized in seven steps in 45% overall yield from ferrocenyloxazoline derived from (S)-valinol. The new chiral phosphine has only planar chirality, and is able to form a trans-chelate metal complex. (S,S)-EtTRAP-H is an effective ligand in rhodium-catalyzed asymmetric hydrosilylation of ketones (up to 94% ee). In particular, the hydrosilylation of 2-octanone yielded (S)-2-octanol with 77% ee.

• 出版日期2004-7-26