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摘要
A new method for simultaneous determination of six benzoic acid esters and their metabolite p-hydroxybenzoic acid (p-HB) in sediments was developed. The samples were extracted with methanol and water, and then the extraction was purified by Oasis MCX solid phase column. The separation of targets was conducted by passing through a UPLC (R) HSS T3 column with a methanol-0.1% acid aqueous solution as the mobile phase under gradient elution. The qualitative analysis of the analytes was measured by Ultra performance liquid chromatography-Triple quadrupole tandem mass under multiple reaction monitoring mode (MRM) and the internal standard method was applied for quantitative analysis. The results indicated that seven target substances had a good linear relationship in the range of 0.1-500 mu g/L with correlation coefficients above 0.9995 and the detection limits of 0.75-1.23 ng/g. The recoveries ranged from 65.5% to 88.3% and the relative standard deviation was 7.4%-13.6%. This method was suitable for the measurement of benzoic acid esters with the advantages such as simple processing, good selectivity and high sensitivity.
- 出版日期2018-2
- 单位河南师范大学
