Development of Multiple Types of Neurochips

作者：Tang Rongyu; Zhang Li; Li Junjie; Wang Changyong; Liu Zhiqiang; Han Yao; Lin Qiuxia^*

来源：Journal of Biomaterials and Tissue Engineering, 2014, 4(12): 1004-1011.

DOI：10.1166/jbt.2014.1247

• Microelectrode Array
• Neurochip
• Tissue Engineering
• Neural Culture

The biological activity of neural tissue and cells are constantly influenced by and closely related to the surrounding microenvironment. The ability to construct and control microenvironment is essential for many neuroscientific studies, including tissue engineering, stem cell differentiation induction, in vitro drug screening and disease models. In the past 40 years multiple types of neurochips emerged in responding to the needs of neuroscience research in vitro adopting the state-of-the-art microfabrication and microelectronics technologies. Microfabrication techniques were used to construct three-dimensional structures, e.g., the tissue culture scaffold, perfusion microfluidics or microenvironment recreation, according to the requirement of experiments, either providing forces to capture and separate cells, guidance cue to distribute cells and construct tissue or transportation to deliver oxygen, drug and nutrition. The neurochip integrating bioelectric sensors and functional circuits further acquired the capabilities of signal detection, cell stimulation and data analysis, becoming a multi-functional platform of neuroscience research. This review presented the classification, the manufacture techniques, the development history and the application of neurochips. The progress of our laboratory in developing multiple types of neurochips and system was also introduced.

• 出版日期2014-12
• 单位中国人民解放军军事医学科学院