Medium-Chain Fatty Acids Enhanced the Excretion of Fecal Cholesterol and Cholic Acid in C57BL/6J Mice Fed a Cholesterol-Rich Diet

作者：Xu, Qing; Xue, Changyong^*; Zhang, Yong; Liu, Yinghua; Wang, Jin; Yu, Xiaoming; Zhang, Xinsheng; Zhang, Rongxin; Yang, Xueyan; Guo, Changjiang

来源：Bioscience Biotechnology and Biochemistry, 2013, 77(7): 1390-1396.

DOI：10.1271/bbb.120999

• medium-chain fatty acids
• cholesterol
• fecal neutral steroids
• fecal bile acid
• cholesterol 7 alpha-hydroxylase

The objective of the present study was to investigate the cholesterol-reducing effect of medium-chain fatty acids (MCFAs) completed by elevated excretion of fecal neutral steroids and/or bile acids. Blood and liver lipid profiles, fecal neutral steroids, bile acids, and mRNA and protein expression of the genes relevant to cholesterol homeostasis were measured and analyzed in C57BL/6J mice fed a cholesterol-rich diet with 2% caprylic acid or capric acid for 12 weeks. Blood total cholesterol and low-density lipoprotein cholesterol (LDL-c) levels were reduced significantly as compared to diet with palmitic acid or stearic acid. Caprylic acid promoted the excretion of fecal neutral steroids, especially cholesterol. The excretion of fecal bile acids, mainly in the form of cholic acid was enhanced and accompanied by elevated expression of mRNA and the protein of hepatic cholesterol 7 alpha-hydroxylase (CYP7A1). These results indicate that MCFAs can reduce blood cholesterol by promoting the excretion of fecal cholesterol and cholic acid.

• 出版日期2013-7
• 单位中国人民解放军军事医学科学院; 中国人民解放军总医院