Association between survivin 31G > C polymorphism and cancer risk: evidence from 33 case-control studies of 8028 cases and 9618 controls

作者：Zheng, Xiaodong^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(2): 965-977.

• Survivin
• rs990434
• polymorphism
• susceptibility
• meta-analysis
• cancer

Survivin is an inhibitor of apoptosis proteins and plays a crucial role in the development of cancer. Numerous studies have evaluated the association between survivin 31G>C polymorphism (rs9904341) and the risk of cancer, but the results of these studies remain inconclusive. Therefore, we conducted this updated meta-analysis to further examine this association. A total of 33 studies of 8028 cases and 9618 controls were identified. Overall, cancer risk was significantly elevated in the dominant model (OR = 1.170, 95% CI = 1.027-1.333), recessive model (OR = 1.387, 95% CI = 1.209-1.590), allele contrast model (OR = 1.192, 95% CI = 1.083-1.312) and homozygous codominant model (OR = 1.443, 95% CI = 1.214-1.714). A subgroup analysis by ethnicity identified a significant association among Asian populations under all genetic models. Furthermore, a subgroup analysis by cancer type showed a significant association between rs9904341 and gastric, colorectal and bladder cancers. Specifically, the correlation with colorectal cancer was significant in both the Asian and Caucasian populations, whereas the lung cancer and bladder cancer associations were significant in the Asian population, and the gastric cancer association was significant in the Caucasian population. Taken together, our results demonstrate that survivin 31G>C polymorphism is an important genetic risk factor of cancer.

• 出版日期2016
• 单位重庆市肿瘤研究所