Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes

作者:Martin Veronique I; Goodell John R; Ingham Oscar J; Porco John A Jr; Beeler Aaron B*
来源:Journal of Organic Chemistry, 2014, 79(9): 3838-3846.
DOI:10.1021/jo500190b

摘要

We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes.

  • 出版日期2014-5-2