Mechanisms of sensorineural cell damage, death and survival in the cochlea

作者：Wong Ann C Y; Ryan Allen F

来源：Frontiers in Aging Neuroscience, 2015, 7: 58.

DOI：10.3389/fnagi.2015.00058

• presbycusis
• age-related hearing loss (ARHL)
• hair cells (HCs)
• spiral ganglion neurons (SGN)
• reactive oxygen species (ROS)
• c-Jun terminal kinase (JNK)
• inflammation
• cell survival signaling

The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well as the survival signaling pathways that can provide endogenous protection and tissue rescue. These data have primarily been generated in hearing loss not directly related to age. However, there is evidence that similar mechanisms operate in presbycusis. Moreover, accumulation of damage from other causes can contribute to age-related hearing loss (ARHL). Potential therapeutic interventions to balance opposing but interconnected cell damage and survival pathways, such as antioxidants, anti-apoptotics, and pro inflammatory cytokine inhibitors, are also discussed.

• 出版日期2015-4-21