A Killer-Protector System Regulates Both Hybrid Sterility and Segregation Distortion in Rice

作者：Yang, Jiangyi; Zhao, Xiaobo; Cheng, Ke; Du, Hongyi; Ouyang, Yidan; Chen, Jiongjiong; Qiu, Shuqing; Huang, Jianyan; Jiang, Yunhe; Jiang, Liwen; Ding, Jihua; Wang, Jia; Xu, Caiguo; Li, Xianghua; Zhang, Qifa^*

来源：Science, 2012, 337(6100): 1336-1340.

DOI：10.1126/science.1223702

• PROGRAMMED CELL-DEATH
• INDICA-JAPONICA HYBRIDS
• ORYZA-SATIVA L.
• WIDE-COMPATIBILITY
• REPRODUCTIVE BARRIER
• S-5 LOCUS
• GENE
• INCOMPATIBILITY
• ARABIDOPSIS
• STRESS

Hybrid sterility is a major form of postzygotic reproductive isolation that restricts gene flow between populations. Cultivated rice (Oryza sativa L.) consists of two subspecies, indica and japonica; inter-subspecific hybrids are usually sterile. We show that a killer-protector system at the S5 locus encoded by three tightly linked genes [Open Reading Frame 3 (ORF3) to ORF5] regulates fertility in indica-japonica hybrids. During female sporogenesis, the action of ORF5+ (killer) and ORF4+ (partner) causes endoplasmic reticulum (ER) stress. ORF3+ (protector) prevents ER stress and produces normal gametes, but ORF3- cannot prevent ER stress, resulting in premature programmed cell death and leads to embryo-sac abortion. Preferential transmission of ORF3+ gametes results in segregation distortion in the progeny. These results add to our understanding of differences between indica and japonica rice and may aid in rice genetic improvement.

• 出版日期2012-9-14
• 单位华中农业大学