Necitumumab: a new option for first-line treatment of squamous cell lung cancer

作者：Jimenez Aguilar Elizabeth; Zugazagoitia Fraile Jon; Paz Ares Rodriguez Luis

来源：Expert Opinion on Drug Metabolism and Toxicology, 2018, 14(8): 765-772.

DOI：10.1080/17425255.2018.1498839

• Epidermal growth factor receptor (EGFR)
• monoclonal antibody
• necitumumab
• IMC-11F8
• non-small-cell lung cancer (NSCLC)
• squamous cell carcinoma(SCC)

Introduction: First-line treatment with platinum-based chemotherapy has been the standard treatment for non-small-cell lung cancer (NSCLC) during the past decades. The development of new targeted drugs based on molecular alterations (EGFR, ALK, and ROS1) has led to important outcome benefits, but not for squamous cell carcinoma (SCC). However, the aberrant function of the EGFR pathway in SCC may be important in the development of the tumor and has been explored in preclinical and clinical studies as a potential target.
Areas covered: Necitumumab is a human IgG1 anti-EGFR antibody that binds to the receptor and inhibits further pathway activation, thereby inhibiting cell differentiation, proliferation and migration. The phase III SQUIRE trial was a randomized study of gemcitabine-cisplatin plus necitumumab versus gemcitabine-cisplatin alone for first-line stage IV squamous NSCLC, showing a higher overall survival and better disease control with the addition of necitumumab. Despite the good results, the lack of robust predictive biomarkers makes the selection of the patients who will benefit the most complex.
Expert opinion: Necitumumab plus cisplatin-gemcitabine is a first-line treatment option in SCC that improves overall survival and preserves the patient's quality of life with a manageable toxicity profile.

• 出版日期2018