ASSOCIATION BETWEEN ANATOMICAL RESOLUTION AND FUNCTIONAL OUTCOMES IN THE MIVI-TRUST STUDIES USING OCRIPLASMIN TO TREAT SYMPTOMATIC VITREOMACULAR ADHESION/VITREOMACULAR TRACTION, INCLUDING WHEN ASSOCIATED WITH MACULAR HOLE

作者：Gandorfer Arnd^*; Benz Matthew S; Haller Julia A; Stalmans Peter; Pakola Stephen J; Girach Aniz; Kampik Anselm; Toth Cynthia A; Jaffe Glenn J

来源：Retina-The Journal of Retinal and Vitreous Diseases, 2015, 35(6): 1151-1157.

DOI：10.1097/IAE.0000000000000508

Purpose:
To evaluate visual function in patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction including when associated with macular hole after ocriplasmin treatment, and the association between resolution of the underlying condition and improvement in visual function.
Methods:
Six hundred and fifty-two patients from 2 Phase 3 trials received a single intravitreal injection of ocriplasmin 125 mu g (n = 464) or placebo (n = 188). Mean and categorical changes from baseline in best-corrected visual acuity and 25-item Visual Function Questionnaire scores were used to evaluate visual function. Subgroups with VMA resolution and full-thickness macular hole closure were compared.
Results:
Overall, 42% of patients who achieved VMA resolution at Day 28 had a >= 2-line improvement in best-corrected visual acuity at Month 6, and 20% had a >= 3-line improvement. Likewise, 69% of patients with nonsurgical full-thickness macular hole closure at Day 28 had a >= 2-line improvement at Month 6, and 48% had a >= 3-line best-corrected visual acuity improvement. Mean improvements in 25-item Visual Function Questionnaire scores were associated with achieving VMA resolution and nonsurgical full-thickness macular hole closure.
Conclusion:
In patients with symptomatic VMA/vitreomacular traction, VMA resolution and nonsurgical full-thickness macular hole closure were each associated with improvements in visual function. Resolving the underlying anatomical condition in symptomatic VMA/vitreomacular traction will increase the probability of achieving a clinically meaningful improvement in visual function.

• 出版日期2015-6