Diffuse optical tomography changes correlate with residual cancer burden after neoadjuvant chemotherapy in breast cancer patients

作者：Lim Emerson A^*; Gunther Jacqueline E; Kim Hyun K; Flexman Molly; Hibshoosh Hanina; Crew Katherine; Taback Bret; Campbell Jessica; Kalinsky Kevin; Hielscher Andreas; Hershman Dawn L

来源：Breast Cancer Research and Treatment, 2017, 162(3): 533-540.

DOI：10.1007/s10549-017-4150-7

• Breast cancer
• Neoadjuvant chemotherapy
• Diffuse optical tomography
• Imaging

Breast cancer (BC) patients who achieve a favorable residual cancer burden (RCB) after neoadjuvant chemotherapy (NACT) have an improved recurrence-free survival. Those who have an unfavorable RCB will have gone through months of ineffective chemotherapy. No ideal method exists to predict a favorable RCB early during NACT. Diffuse optical tomography (DOT) is a novel imaging modality that uses near-infrared light to assess hemoglobin concentrations within breast tumors. We hypothesized that the 2-week percent change in DOT-measured hemoglobin concentrations would associate with RCB.
We conducted an observational study of 40 women with stage II-IIIC BC who received standard NACT. DOT imaging was performed at baseline and 2 weeks after treatment initiation. We evaluated the associations between the RCB index (continuous measure), class (categorical 0, I, II, III), and response (RCB class 0/I = favorable, RCB class II/III = unfavorable) with changes in DOT-measured hemoglobin concentrations.
The RCB index correlated significantly with the 2-week percent change in oxyhemoglobin [HbO(2)] (r = 0.5, p = 0.003), deoxyhemoglobin [Hb] (r = 0.37, p = 0.03), and total hemoglobin concentrations [HbT] (r = 0.5, p = 0.003). The RCB class and response significantly associated with the 2-week percent change in [HbO(2)] (p ae<currency> 0.01) and [HbT] (p ae<currency> 0.02). [HbT] 2-week percent change had sensitivity, specificity, positive, and negative predictive values for a favorable RCB response of 86.7, 68.4, 68.4, and 86.7%, respectively.
The 2-week percent change in DOT-measured hemoglobin concentrations was associated with the RCB index, class, and response. DOT may help guide NACT for women with BC.

• 出版日期2017-4