First total synthesis of topopyrone C

作者：Gattinoni Sonia; Merlini Lucio; Dallavalle Sabrina^*

来源：Tetrahedron Letters, 2007, 48(6): 1049-1051.

DOI：10.1016/j.tetlet.2006.11.164

• topopyrone C
• synthesis
• anthraquinone
• topoisomerase
• Marschalk reaction

The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase 1, has been carried out by Mars-chalk alkylation of 1-hydroxy-3,6,8-trimethoxyanthraquinone, followed by a Baker-Venkataraman chain elongation and an acidcatalyzed cyclization for the construction of the pyrone ring.

• 出版日期2007-2-5