Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater

作者：Zhou Simon Ningsun^*; Reiner Eric J; Marvin Chris; Helm Paul; Riddell Nicole; Dorman Frank; Misselwitz Michelle; Shen Li; Crozier Patrick; MacPherson Karen; Brindle Ian D

来源：Analytical and Bioanalytical Chemistry, 2010, 396(3): 1311-1320.

DOI：10.1007/s00216-009-3279-6

• Atmospheric pressure chemical ionization (APCI)
• Liquid chromatography tandem mass spectrometry (LC-MS/MS)
• Halogenated flame retardants (HFRs)
• Wastewater

Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandemmass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 mu L injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LCAPCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.

• 出版日期2010-2