A novel VHL alpha isoform inhibits Warburg effect via modulation of PKM splicing

作者：Liu Yanbin^*; Yang Haixia; Li Lin; Chen She; Zuo Feifei; Chen Liang^*

来源：Tumor Biology, 2016, 37(10): 13649-13657.

DOI：10.1007/s13277-016-5191-y

• VHL
• Alternative translation
• hnRNPA2B1
• Pyruvate kinase
• Glucose metabolism

Von Hippel-Lindau (VHL) is the most frequently mutated gene in clear cell renal carcinoma. Here, we identified a novel translational variant of VHL, termed VHL alpha, initiated from an alternative translational start site upstream and in frame with the ATG start codon. We showed that VHL alpha interacts with and regulates heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1), which consequently modulates pyruvate kinase transcript splicing and reprograms cellular glucose metabolism. Our study demonstrated that a novel VHL isoform may function as a tumor suppressor through inhibiting the Warburg effect.

• 出版日期2016-10
• 单位北京生命科学研究所