Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia

作者：Takahashi Sakae; Cui Yu hu; Han Yong hua; Fagerness Jesen A; Galloway Brian; Shen Yu cun; Kojima Takuya; Uchiyama Makoto; Faraone Stephen V; Tsuang Ming T^*

来源：Schizophrenia Research, 2008, 104(1-3): 153-164.

DOI：10.1016/j.schres.2008.05.028

• schizophrenia
• chromosome 22
• APOL gene family cluster
• APOL1
• AOPL2
• APOL4

Prior work found the A POL1, 2 and 4 genes, located on chromosome 22q12.3-q113.1, to be upreaulated in brains of schizophrenic patients, We performed a family-based association study using 130 SNPs tagging the APOL gene family (APOL1-6). The Subjects were 112 African-American (AA), 114 European-American (EA), 109 Chinese (Ch) and 42 Japanese (Jp) families with schizophrenia (377 families, 1161 genotyped members and 647 genotyped affected in total). Seven SNPs had p-values< 0.05 in the APOL1, 2 and 4 regions for the AA, EA and combined (AA and EA) samples. In the AA sample, two SNPs, rs9610449 and rs6000200 showed low p-values; and a haplotype which comprised these two SNPs yielded a p-value of 0.00029 using the global test (GT) and the allele specific test (AST). The two SNPs and the haplotype were associated with risk for schizophrenia in African-Americans. In the combined (AA and EA) sample, two SNPs, rs2003813 and rs2157249 showed low p-values; and a three SNP haplotype including these two SNPs was significant using the GT (p = 0.0013) and the AST (p = 0.000090). The association of this haplotype with schizophrenia was significant for the entire (AA, EA, Ch and Jp) sample using the GT (p = 0.00054) and the AST (p = 0.00011).

• 出版日期2008-9
• 单位北京大学; 上海市精神卫生中心