Decoy receptor 3 is highly expressed in patients with rheumatoid arthritis

作者：Hayashi Shinya; Miura Yasushi^*; Tateishi Koji; Takahashi Masayasu; Kurosaka Masahiro

来源：Modern Rheumatology, 2010, 20(1): 63-68.

DOI：10.1007/s10165-009-0240-7

• Rheumatoid arthritis
• Osteoarthritis
• Decoy receptor 3
• TNF-alpha

Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor (TNFR) superfamily, is a soluble receptor that binds to the TNF family including Fas ligand (Fas-L), LIGHT, and TL1A. DcR3 is mostly expressed in tumor cells and competitively inhibits the TNF family. We previously demonstrated that overexpressed DcR3 in rheumatoid synovial cells protects the cells from apoptosis in vitro. The objective of the study was to investigate DcR3 expression in serum and joint fluids of patients with rheumatoid arthritis (RA) and osteoarthritis (OA), and to analyze the correlations with disease activities and TNF alpha expression. Sera and joint fluids were collected from patients with RA and OA. Expression of DcR3 in sera and joint fluids was measured by ELISA. The concentration of DcR3 in sera and joint fluids of RA patients was significantly higher than that in sera and joint fluids of OA patients. A correlation between serum DcR3 concentration and disease activity was not observed, but the serum DcR3 concentration was strongly correlated with the TNF alpha concentration. DcR3 was highly expressed in serum and joint fluids of RA patients.

• 出版日期2010-2