Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis

作者：Govindaraj Periyasamy; Khan Nahid Akhtar; Gopalakrishna Praturi; Chandra Rampalli Viswa; Vanniarajan Ayyasamy; Reddy Aileni Amarendra; Singh Shashi; Kumaresan Rathinam; Srinivas Gunda; Singh Lalji; Thangaraj Kumarasamy^*

来源：Mitochondrion, 2011, 11(3): 504-512.

DOI：10.1016/j.mito.2011.01.009

• Chronic periodontitis
• Mitochondria
• mtDNA
• Mutations
• ROS

We performed an extensive study on mitochondrial dysfunction in chronic periodontitis (CP). Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of the patients. Mitochondrial membrane potential and oxygen consumption of gingival cells were reduced by 4 fold and 5.8 fold, respectively; whereas ROS production was increased by 18%. The genetic analysis by complete mitochondrial DNA sequencing revealed the identification of 14 novel mutations only in periodontal tissues but not in the blood, suggesting a role of oxidative stress on periodontal tissues. Thus, our functional and genetic analysis provided an evidence for the mitochondrial dysfunction in CP.

• 出版日期2011-5