Ascl2 Reinforces Intestinal Stem Cell Identity

作者：Yan Kelley S; Kuo Calvin J^*

来源：Cell Stem Cell, 2015, 16(2): 105-106.

DOI：10.1016/j.stem.2015.01.014

Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5(+) intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers et al. (2015) report an Ascl2 positive feedback loop, tuned by previous Wnt pathway activity, that perpetuates intestinal stem cell identity in response to Wnt/R-spondin stimulation.

• 出版日期2015-2-5