Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H-barbatum Jacq., H-hirsutum L., H-richeri Vill. and H-androsaemum L. in rats

作者：Savikin Katarina^*; Dobric Silva; Tadic Vanja; Zdunic Gordana

来源：Phytotherapy Research, 2007, 21(2): 176-180.

DOI：10.1002/ptr.2041

• Hypericum species
• hypericin
• antiinflammatory activity
• indomethacin

Ethanol extracts of the aerial parts of six Hypericum species, H. barbatum, H. androsaemum, H. richerii, H. hirsutum, H. perforatum and H. perforatum cultivated on mountain Tara were tested for antiinflammatory activity in comparison with indomethacin (IND) using the carrageenan-induced rat paw edema test. It was found that all examined extracts produced antiinflammatory activity, particularly those from H. hirsutum, and both wild and cultivated H. perforatum. A dose-dependent antiinflammatory effect was especially pronounced in extracts showing some lower antiinflammatory activity. There was no correlation between the amount of hypericin in the extracts and their antiinflammatory activity.

• 出版日期2007-2
• 单位河北医科大学