Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP)

作者：Friedrich Nele^*; Krebs Alexander; Nauck Matthias; Wallaschofski Henri

来源：Clinical Chemistry and Laboratory Medicine, 2010, 48(1): 115-120.

DOI：10.1515/CCLM.2010.009

• Immulite 2500
• insulin-like growth factor I
• insulin-like growth factor binding protein
• quantile regression
• references ranges
• Study of Health in Pomerania (SHIP)

Background: The objective of the present study was to calculate age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) concentrations using quantile regression.
Methods: From the Study of Health in Pomerania (SHIP), 1798 men and women aged 25-85 years were recruited. Serum IGF-I and IGFBP-3 concentrations were determined using a chemiluminescent immunometric assay on an Immulite 2500 (R) analyzer. Quantile regressions were performed to calculate the 2.5th and 97.5th percentiles.
Results: The reference ranges identified 43 (4.6%) women and 41 (4.8%) men with serum IGF-I concentrations, and 47 (5.0%) women and 42 (5.0%) men with serum IGFBP-3 concentrations outside the reference range.
Conclusions: The use of quantile regression results in accurate calculation of age- and gender-specific reference ranges for serum IGF-I and IGFBP-3. Clin Chem Lab Med 2010; 48: 115-20.

• 出版日期2010-1