An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders

作者：Camins Antoni^*; Xavier Sureda Francesc; Junyent Felix; Verdaguer Ester; Folch Jaume; Beas Zarate Carlos; Pallas Merce

来源：Expert Opinion on Investigational Drugs, 2010, 19(5): 587-604.

DOI：10.1517/13543781003781898

Areas covered in this review: The present review discusses some of the drugs that are now under development with antiapoptotic activity or currently on the market that may have a potential application for the treatment of neurodegenerative diseases. Moreover, we also comment on potential compounds such as resveratrol and melatonin. Despite the lack of information from clinical trials on these two compounds, they are attracting considerable attention because of their natural origin and antioxidant and antiapoptotic action. Furthermore, they do not show toxicity in humans. In addition, we discuss the potential application of several compounds, such as NMDA antagonists, JNK inhibitors and GSK-3 inhibitors, for the treatment of neurodegenerative disorders.
What the reader will gain: This article will review recent developments in the field of apoptosis inhibitors, which might provide future tools for the treatment of the neurodegenerative diseases.
Take home message: The treatment of neurodegenerative diseases is a major challenge in medicine. This is partly because the incidence of these disorders is expected to rise in the coming years. New developments in the field of apoptosis inhibitors may provide future tools for the treatment of the aforementioned neurodegenerative diseases.

• 出版日期2010-5