Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide

作者：Haller Michael J^*; Wasserfall Clive H; Hulme Maigan A; Cintron Miriam; Brusko Todd M; McGrail Kieran M; Sumrall Theresa M; Wingard John R; Theriaque Douglas W; Shuster Jonathan J; Atkinson Mark A; Schatz Desmond A

来源：Diabetes Care, 2011, 34(12): 2567-2569.

DOI：10.2337/dc11-1406

OBJECTIVE-We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the complete cohort after 2 years of follow-up.
RESEARCH DESIGN AND METHODS-A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments.
RESULTS-No infusion-related adverse events were observed. beta-Cell function declined after UCB infusion. Area under the curve C-peptide was 24.3% of baseline 1 year postinfusion (P < 0.001) and 2% of baseline 2 years after infusion (P < 0.001). Flow cytometry revealed increased regulatory T cells (Tregs) (P = 0.04) and naive Tregs (P = 0.001) 6 and 9 months after infusion, respectively.
CONCLUSIONS-Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide.

• 出版日期2011-12