Differential responses of human liver cancer and normal cells to atmospheric pressure plasma

作者：Gweon Bomi; Kim Mina; Kim Dan Bee; Kim Daeyeon; Kim Hyeonyu; Jung Heesoo; Shin Jennifer H^*; Choe Wonho

来源：Applied Physics Letters, 2011, 99(6): 063701.

DOI：10.1063/1.3622631

When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal cells (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at the electrode of the micro-plasma jet source, above which SK-HEP-1 started to detach from the substrate while THLE-2 remained intact. Our mechanical and biochemical analyses confirmed the presence of intrinsic differences in the adhesion properties between the cancer and the normal liver cells, which provide a clue to the differential detachment characteristics of cancer and normal cells to the atmospheric pressure plasma.

• 出版日期2011-8-8