Decreased plasma gelsolin is associated with 1-year outcome in patients with traumatic brain injury

作者：Jin, Yong^*; Li, Bo-You; Qiu, Ling-Li; Ling, Yuan-Ren; Bai, Zhi-Qiang

来源：Journal of Critical Care, 2012, 27(5): 527.e1.

DOI：10.1016/j.jcrc.2012.01.002

• Gelsolin
• Traumatic brain injury
• 1-year outcome

Purpose: Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients. @@@ Methods: One hundred fourteen healthy controls and 114 patients with acute severe TBI were included in this study. Plasma gelsolin concentration on admission was measured by ELISA. @@@ Results: Fifty-five patients (48.2%) had unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 38 patients (33.3%) died in 1 year after TBI. Upon admission, plasma gelsolin level in patients was substantially lower than that in healthy controls. A multivariate analysis selected plasma gelsolin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma gelsolin level predicted 1-year unfavorable outcome and mortality statistically significantly. The predictive value of the gelsolin concentration was thus similar to that of Glasgow Coma Scale (GCS) score. In a combined logistic-regression model, gelsolin did not statistically significantly improve the area under curve of GCS score. @@@ Conclusions: Plasma gelsolin level is a useful, complementary tool to predict functional outcome and mortality 1 year after TBI.

• 出版日期2012-10
• 单位台州学院