A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: Results of a meta-analysis of randomized, placebo-controlled trials

作者：Musa Veloso Kathy^*; Poon Theresa H; Elliot Julie Ann; Chung Catherine

来源：Prostaglandins, Leukotrienes and Essential Fatty Acids, 2011, 85(1): 9-28.

DOI：10.1016/j.plefa.2011.02.001

• Plant stanols
• Plant sterols
• Phytostanols
• Phytosterols
• Plant stanol ester
• Plant sterol ester
• LDL-cholesterol
• Dose-response
• Meta-analysis

Purpose: To determine if plant stanols and plant sterols differ with respect to their low-density lipoprotein cholesterol (LDL-CH) lowering efficacies across a continuous dose range.
Methods: Dose-response relationships were evaluated separately for plant stanols and plant sterols and reductions in LDL-CH, using a first-order elimination function.
Results: Altogether, 113 publications and 1 unpublished study report (representing 182 strata) complied with the pre-defined inclusion and exclusion criteria and were included in the assessment. The maximal LDL-CH reductions for plant stanols (16.4%) and plant stanol ester (17.1%) were significantly greater than the maximal LDL-CH reductions for plant sterols (8.3%) and plant sterol ester (8.4%). These findings persisted in several additional analyses.
Discussion and conclusions: Intakes of plant stanols in excess of the recommended 2 g/day dose are associated with additional and dose-dependent reductions in LDL-CH, possibly resulting in further reductions in the risk of coronary heart disease (CHD).

• 出版日期2011-7