A sensitive amplified sensor based on improved carbon paste electrode with 1-methyl-3-octylimidazolium tetrafluoroborate and ZnO/CNTs nanocomposite for differential pulse voltammetric analysis of raloxifene

作者：Cheraghi Somaye^*; Taher Mohammad Ali; Karimi Maleh Hassan^*

来源：Applied Surface Science, 2017, 420: 882-885.

DOI：10.1016/j.apsusc.2017.05.218

• Raloxifene
• ZnO/CNTs nanocomposite
• Modified electrodes
• Voltammetry

In this work, we suggested a carbon paste electrode improved with 1-methyl-3-octylimidazolium tetrafluoroborate (1-M-3-OITFB) and ZnO/CNTs nanocomposite (1-M-3-OITFB/ZnO/CNTs/CPE) for electrochemical determination of raloxifene (RXF) as a non-steroidal selective estrogen receptor regulator. The cyclic and differential pulse voltammetric methods were apply for investigation of RXF electrochemical response at a surface of 1-M-3-OITFB/ZnO/CNTs/CPE. Under the best experimental conditions, the 1-M-3-OITFB/ZnO/CNTs/CPE showed a wide linear dynamic range of 0.08 - 400.0 mu M. We detected a detection limit of 0.04 mu M for RXF analysis using differential pulse voltammetric method (DPV). The 1-M-3-OITFB/ZnO/CNTs/CPE showed high performance ability to RXF analysis in trace amounts on pharmaceutical and clinical preparations.

• 出版日期2017-10-31