A rapid, mild, and efficient method for C-5 iodination/thiocyanation of 2-aminothiazoles

作者：Hebade Madhav J; Kamble Rahul D; Hese Shrikant V; Mogle Pratima P; Ambhore Ajay N; Kadam Shuddhodan N; Dawane Bhaskar S^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191(8): 1155-1159.

DOI：10.1080/10426507.2016.1149851

• Aq
• PEG-400
• iodination
• thiocyanation
• iodic acid
• 2-aminothiazole

An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate respectively. Iodic acid was found to be a good oxidant and aqueous PEG-400 as green reaction solvent.

• 出版日期2016