Anxiety and self-perceived health status in Parkinson's disease

作者：Pontone Gregory M^*; Williams James R; Anderson Karen E; Chase Gary; Goldstein Susanne R; Grill Stephen; Hirsch Elaina S; Lehmann Susan; Little John T; Margolis Russell L; Rabins Peter V; Weiss Howard D; Marsh Laura

来源：Parkinsonism & Related Disorders, 2011, 17(4): 249-254.

DOI：10.1016/j.parkreldis.2011.01.005

• Parkinson's disease
• Non-motor symptoms
• Anxiety
• Psychiatric disorders
• Quality of life
• Fluctuations

Both anxiety and depression are associated with lower self-perceived health status (HS) in persons with Parkinson's disease (PD). Given the high co-morbidity with depression and other non-motor symptoms, it is unclear whether anxiety disorders, in general, versus specific anxiety subtypes have an independent effect on HS in PD. To examine this question, comprehensive assessments of motor and non-motor symptoms from 249 subjects with idiopathic PD followed in three community-based movement disorders neurology practices were analyzed. HS was measured using the 8-item PD Questionnaire (PDQ-8). Psychiatric diagnoses were established by consensus using a panel of six psychiatrists with expertise in geriatric psychiatry and movement disorders. Stepwise multiple regression analyses were used, with the PDQ-8 score as the dependent variable, to identify independent predictors of HS among motor, psychiatric, and other non-motor variables. Among the anxiety disorders, only anxiety associated with motor fluctuations was an independent predictor of HS after accounting for co-morbid depression and other clinical features. In addition, depressive disorders were also an independent predictor of lower HS. Prevention or treatment of state-dependent anxiety may improve HS in persons with PD.

• 出版日期2011-5