Association of adipokines, interleukin-6, and tumor necrosis factor-alpha concentrations with clinical characteristics and presence of spinal syndesmophytes in patients with ankylosing spondylitis: A cross-sectional study

作者：Gonzalez Lopez Laura; Fajardo Robledo Nicte S; Miriam Saldana Cruz A; Moreno Sandoval Inocente V; Bonilla Lara David; Zavaleta Muniz Soraya; Hernan Nava Zavala Arnulfo; Hernandez Cuervo Paulina; Rocha Munoz Alberto; Alejandra Rodriguez Jimenez Norma; Vazquez Villegas Maria L; Francisco Munoz Valle J; Salazar Paramo Mario; Cardona Munoz Ernesto G; Gamez Nava Jorge I^*

来源：Journal of International Medical Research, 2017, 45(3): 1024-1035.

DOI：10.1177/0300060517708693

• Ankylosing spondylitis
• body composition
• interleukin-6
• tumor necrosis factor-alpha
• leptin
• adiponectin
• syndesmophytes

Objective To identify correlations of the serum leptin, adiponectin, interleukin-6 (IL-6), and tumor necrosis factor- (TNF-) concentrations with the clinical characteristics, presence of spinal syndesmophytes, and body composition in patients with ankylosing spondylitis (AS).
Methods Forty-eight patients with AS were compared with 41 sex- and age-matched controls. Assessment included clinical characteristics and the presence of spinal syndesmophytes. The serum leptin, adiponectin, TNF-, and IL-6 concentrations were determined. Body composition was evaluated using dual-energy X-ray absorptiometry.
Results Patients with AS and controls had similar fat mass and lean mass. Patients with AS had higher serum TNF- and leptin concentrations than controls (52.3 vs. 1.5pg/mL and 17.2 vs. 9.0 mu g/mL, respectively). The IL-6 and adiponectin concentrations were not significantly different between the two groups. Patients with syndesmophytes had higher leptin concentrations than those without syndesmophytes (22.1 vs. 10.9 mu g/mL); this difference remained after adjustment for the body mass index.
Conclusion Elevated leptin concentrations are associated with spinal radiographic damage in patients with AS and can serve as a biomarker. Future studies should evaluate whether leptin might be a potential target for treatments to avoid structural damage.

• 出版日期2017-6