Molecular and Nanotechnologic Approaches to Etiologic Diagnosis of Infectious Syndromes

作者：Sankar Sathish^*; Ramamurthy Mageshbabu; Nandagopal Balaji; Srikanth Padma; Venkatraman Ganesh; Sridharan Gopalan

来源：Molecular Diagnosis & Therapy, 2011, 15(3): 145-158.

Infectious diseases are a major global public health problem. Multiple agents are now recognized to cause indistinguishable illnesses. The term 'syndrome' applies to such situations, for which early and rapid diagnosis of the infecting agent would enable prompt and appropriate therapy. Public health physicians would also get timely information on the specific etiology of the infectious syndrome, facilitating intervention at the community level in the face of outbreaks or epidemics. A variety of molecular techniques have been evaluated for rapid diagnosis of infectious syndromes. These techniques include real-time multiplex PCR, DNA microarray, loop-mediated isothermal amplification, and other similar assays. This review surveys such state-of-the-art technologies.

• 出版日期2011